目的 对北葶苈子(Lepidium apetalum Willd.)化学成分进行研究。方法 运用Silica gel, ODS, Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20等柱色谱技术结合半制备液相等方法对其进行分离纯化,并根据化合物的波谱数据和理化性质进行结构鉴定。结果 从其水提物中分离并鉴定了16个化合物,即:儿茶酚(1), 原儿茶醛(2), 2-苯乙酰胺(3), 5-羟基吡啶-2-甲酸甲酯(4), benzylcarbamic acid(5), N-苄基甲酰胺(6), raphanuside C(7), 1-phenyl-1,2-ethanediol(8), 2-(4-hydroxyphenyl)-ethanol(9),异鼠李素-7-O-α-L-鼠李糖苷(10), 山柰酚(11), 2,4,6-三甲基-没食子酸(12), 2-(4-hydroxyphenyl) acetonitrile(13), 丁香酸(14), 原儿茶酸(15)和芥子酸甲酯(16)。结论 化合物1~16均为首次从该植物中分离得到。
Abstract
OBJECTIVE To investigate the chemical constituents of the seeds of Lepidium apetalum Willd. METHODS The compounds were isolated and purified by Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel chromatography combined with Pre-HPLC and the structures were identified on the basis of spectral data and physiochemical properties. RESULTS Sixteen compounds were isolated and identified from the water extract as catechol(1), protocatechuic aldehyde(2), 2-phenyl acetamide(3), methyl- 5-hydroxypyridine-2-carboxlate(4), benzylcarbamic acid(5), N-benzylacetamide(6), raphanuside C(7), 1-phenyl-1,2-ethanediol(8), 2-(4-hydroxyphenyl)-ethanol(9), isorhamnetin-7-O-α-L-rhamnopyranoside(10), kaempferol(11), methyl 2,4,6-trihydroxybenzoate(12), 2-(4-hydroxyphenyl)acetonitrile(13), syringic acid(14), protocatechuic acid(15), and methyl sinapate(16). CONCLUSION Compounds 1-16 are isolated from this plant for the first time.
关键词
北葶苈子 /
儿茶酚 /
原儿茶醛 /
2-苯乙酰胺 /
酚酸类
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Key words
the seeds of Lepidium apetalum Willd /
catechol /
protocatechuic aldehyde /
2-pheny lacetamide /
phenolic acids
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中图分类号：
R284
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参考文献
[1] Ch.P(2015) Vol Ⅰ(中国药典2015 年版. 一部) [S]. 2015: 333-334.
[2] HONG J L, QIN M J, WU G, et al. Phenolic constituents of Veronica linariifolia [J]. Chin J Nat Med (中国天然药物杂志), 2008, 6(2):126-129.
[3] XIAO Y, WANG L B, JIN G, et al. Studies on phenolic acid constituents of Acanthopanax sessiliflorus fruits[J]. Chin J Med Chem (中国药物化学杂志),2012, 22(3):223-226.
[4] ZHENG Q, ZHANG Q H, LU D, et al. Chemical constituents in Lepidium meyenii cultivated in Jilin [J]. China Tradit Herb Drugs (中草药), 2014, 45(17):2457-2460.
[5] LI Z F, WANG Q, FENG Y L, et al. Chemical constituents from rhizomes of Coptis chinensis[J]. China Tradit Herb Drugs (中草药), 2012, 43(7):1273-1275.
[6] MA J J,TANG J S, GAO H, et al. Secondary metabolites from Marine actinomycete Streptomyces sp[J]. Chin J Mar Drugs (中国海洋药物杂志), 2010, 29(2):6-9.
[7] LIANG W J, XU H B, YANG C Y, et al. Chemical constituents of Lepidium meyenii [J]. China J Chin Mater Med (中国中药杂志),2015, 40(23):4531-4535.
[8] FENG W S, LI C G, ZHENG X K, et al. Three new sulphur glycosides from the seeds of Descurainia sophia[J]. Nat Prod Res, 2016, 30(15):1675-1681.
[9] QIAO J W, HUANG S W, SONG S J, et al. Study on chemical constituents of the leaves of Diospyros kaki[J]. J Chin Med Mater (中药材), 2016, 39(11):2015-2019.
[10] ZHANG Y L, FENG Z Y, ZHENG X K, et al. Chemical constituents from the leavea of Rehmannia glutinosa Libosch[J]. Chin Pharm J(中国药学杂志), 2014, 49(1):15-21.
[11] ZHANG Z X, ZHANG J, LUO J Q, et al. Chemical constituents of the seeds of Atriplex centralasiatica [J]. J Shenyang Pharm Univ(沈阳药科大学学报), 2008, 25(9):708-710.
[12] WU Y, QU W, GENG D, et al. Phenols and flavonoids from the aerial part of Euphorbia hirta[J]. Chin J Nat Med (中国天然药物杂志), 2012, 10(1):40-42.
[13] HUANG W H, XUE J Y, LI Y L, et al. Study on aromatic chemical constituents of Wikstroemia indica[J]. J Chin Med Mater (中药材), 2008, 31(8):1174-1176.
[14] QU P, LIU P P, FU P, et al. Secondary metabolites of halotolerant fungus penicillium chrysogenum HK14-01 from the Yellow River delta area[J]. Acta Microbiol Sin(微生物学报), 2012, 52(9):1103-1112.
[15] HU J, ZHANG W D, LIU R H, et al. Chemical constituents in root of Zanthoxylum nitidum[J]. China J Chin Mater Med (中国中药杂志), 2006, 31(20):1689-1691.
[16] WANG H L, REN H C, ZOU Z M. Study on antioxidative constituents in rhizomes of Polygonum amplexicaule [J]. Chin Pharm J(中国药学杂志), 2011, 46(11):819-822.
[17] TANG G H, ZHANG Y, HE H P, et al. Chemical constituents from the leaves of Trigonostemon flavidus[J]. Nat Prod Res Dev (天然产物研究与开发), 2013, 25(7):912-915.
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脚注
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基金
科学技术部国家重点基础研究发展计划“973计划”项目资助(2013CB531802)
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